Zalewski A A, Gulati A K
J Neurosurg. 1984 Apr;60(4):828-34. doi: 10.3171/jns.1984.60.4.0828.
This study examined the effect of immunosuppressive treatment with cyclosporin A (Cy-A) on the survival of nerve allografts in sensitized rats. Nerve- or skin-sensitized untreated rats rejected a second nerve allograft of the same genotype as the first in an accelerated manner. In this situation, only a few host axons grew into the proximal 1 cm of a 4 cm-long nerve allograft. However, if sensitized rats were given Cy-A (10 mg/kg daily), the second nerve allograft survived, and numerous host axons regenerated through the 4-cm length of the allograft. These results indicated that Cy-A was an effective immunosuppressive agent in sensitized rats. We conclude that, in rats, donor-specific sensitization is not a contraindication to the use of nerve allografts to aid in the repair of injured nerve when Cy-A is used for immunosuppression.
本研究检测了环孢素A（Cy - A）免疫抑制治疗对致敏大鼠同种异体神经移植物存活的影响。未治疗的神经或皮肤致敏大鼠会以加速方式排斥与首次移植相同基因型的第二次神经同种异体移植物。在这种情况下，只有少数宿主轴突长入4厘米长神经同种异体移植物的近端1厘米。然而，如果给致敏大鼠注射Cy - A（每日10毫克/千克），第二次神经同种异体移植物能够存活，并且大量宿主轴突通过4厘米长的移植物实现再生。这些结果表明，Cy - A在致敏大鼠中是一种有效的免疫抑制剂。我们得出结论，在大鼠中，当使用Cy - A进行免疫抑制时，供体特异性致敏并非使用神经同种异体移植物辅助修复受损神经的禁忌证。
