Broughton R E, deRoos R
Gen Comp Endocrinol. 1984 Feb;53(2):325-30. doi: 10.1016/0016-6480(84)90259-4.
The effects of a single infusion of corticosterone or aldosterone on plasma glucose levels were compared in the American bullfrog (Rana catesbeiana). The corticoids were administered, and serial blood samples were collected, via a cannula placed in the common iliac artery. Plasma glucose was estimated by the glucose oxidase method. Plasma glucose levels were essentially unchanged from the time-zero levels at 3 hr after the infusion of 1.0 mg/100 g body wt of corticosterone. The levels subsequently increased to maxima that were approximately 45% greater than the time-zero levels at 9 through 24 hr and then declined to approximately the initial levels by 48 hr after treatment. Infusion of 0.24 mg/100 g body wt of aldosterone did not significantly alter plasma glucose levels. The results suggest that elevated circulating corticosterone is not involved in the primary hyperglycemic response to a stress, but may function synergistically and sequentially with elevated circulating catecholamines in subsequent compensatory adjustments.
在美国牛蛙（牛蛙）中比较了单次注射皮质酮或醛固酮对血糖水平的影响。通过置于髂总动脉的插管给予皮质类固醇，并采集系列血样。采用葡萄糖氧化酶法估算血浆葡萄糖。在注射1.0mg/100g体重的皮质酮后3小时，血浆葡萄糖水平与零时水平基本无变化。随后水平升高至最大值，在9至24小时比零时水平大约高45%，然后在治疗后48小时降至大约初始水平。注射0.24mg/100g体重的醛固酮未显著改变血浆葡萄糖水平。结果表明，循环皮质酮升高不参与对应激的原发性高血糖反应，但在随后的代偿性调节中可能与循环儿茶酚胺升高协同并相继发挥作用。
