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类风湿关节炎中HLA - B27与骶髂关节受累情况

HLA-B27 and involvement of sacroiliac joints in rheumatoid arthritis.

作者信息

Rantapää Dahlqvist S, Nordmark L G, Bjelle A

出版信息

J Rheumatol. 1984 Feb;11(1):27-32.

PMID:6607994
Abstract

The frequency of radiographic signs of sacroiliac joint involvement (greater than or equal to 2 and greater than or equal to 3 according to the New York criteria) was significantly higher in 28 HLA-B27 positive patients with classical seropositive rheumatoid arthritis (RA), than in 28 B27 negative RA controls. The B27 positive RA patients had more subcutaneous nodules (p less than 0.01), worse functional class (p less than 0.05), and higher levels of erythrocyte sedimentation rate (ESR) (p less than 0.05) and haptoglobin (p less than 0.05). Sacroiliitis, independent of HLA-B27, was associated with higher levels of ESR (p less than 0.05), and with a higher frequency of positive ANA test (p less than 0.05). It is neither related to the functional class nor to the duration of the disease.

摘要

28例HLA - B27阳性的典型血清阳性类风湿关节炎(RA)患者骶髂关节受累的影像学表现频率(根据纽约标准,大于或等于2级和大于或等于3级)显著高于28例B27阴性的RA对照患者。B27阳性的RA患者有更多的皮下结节(p<0.01)、功能分级更差(p<0.05),红细胞沉降率(ESR)水平更高(p<0.05)和触珠蛋白水平更高(p<0.05)。骶髂关节炎,与HLA - B27无关,与ESR水平较高(p<0.05)以及抗核抗体(ANA)检测阳性频率较高(p<0.05)相关。它既与功能分级无关,也与疾病持续时间无关。

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