青少年关节炎患者的临床、人类白细胞抗原（HLA）及放射学随访研究：儿童短暂性和持续性关节炎长期预后的比较
Clinical, HLA, and roentgenological follow up study of patients with juvenile arthritis: comparison between the long term outcome of transient and persistent arthritis in children.
作者信息
Ström H, Lindvall N, Hellström B, Rosenthal L
机构信息
Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden.
出版信息
Ann Rheum Dis. 1989 Nov;48(11):918-23. doi: 10.1136/ard.48.11.918.
Fifty two patients with juvenile chronic arthritis (JCA) and 22 patients with arthritis of short duration (transient arthritis, TA) were studied in a follow up investigation. Nineteen (37%) of the patients with JCA had peripheral arthritis or sequelae in the form of contractures at follow up, and in addition one patient was treated with corticosteroids. In contrast, only one (5%) of the 22 patients with TA had peripheral arthritis at follow up. Back pain or limitation, or both, was registered in many of the men. Sacroiliitis, verified by x ray, was often found both in JCA (39/46, 85%) and in TA (16/21, 76%). For JCA an association was confirmed with HLA-A2 and HLA-DRw8 and a negative association with HLA-DR4, and in pauciarticular JCA, in addition, a decrease of DR7. A new finding was a low prevalence of HLA-B27 in women with JCA and grade 3 or 4 sacroiliitis (2/14, 14%).
在一项随访研究中，对52例青少年慢性关节炎（JCA）患者和22例病程较短的关节炎患者（短暂性关节炎，TA）进行了研究。随访时，19例（37%）JCA患者出现周围关节炎或挛缩形式的后遗症，另外有1例患者接受了皮质类固醇治疗。相比之下，22例TA患者中只有1例（5%）在随访时出现周围关节炎。许多男性出现背痛或背部活动受限，或两者皆有。经X线证实的骶髂关节炎在JCA患者（39/46，85%）和TA患者（16/21，76%）中均经常发现。对于JCA，证实与HLA - A2和HLA - DRw8相关，与HLA - DR4呈负相关，此外，在少关节型JCA中，DR7降低。一项新发现是，患有JCA且骶髂关节炎为3级或4级的女性中，HLA - B27的患病率较低（2/14，14%）。
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