Rundback J H, Rosenberg Z S, Solomon G
Department of Radiology, Beth Israel Medical Center, New York, New York.
Skeletal Radiol. 1993;22(4):263-7. doi: 10.1007/BF00197671.
Radiographs were reviewed in a group of nine patients with classical seropositive rheumatoid arthritis who on tissue typing were found to express the class I HLA-B27 allele. Radiographs were analyzed with regard to whether or not they demonstrated radiographic features of (1) classical rheumatoid arthritis, (2) seronegative arthritis, or (3) mixed features of rheumatoid and seronegative arthritis. Five patients (55%) displayed radiographic features consistent with a diagnosis of rheumatoid arthritis, two patients (22%) showed radiographic features of seronegative disorder (periostitis and sacroiliitis), and two patients (22%) showed a mixed picture with evidence of both rheumatoid arthritis and a seronegative disorder. Thus, the HLA-B27 allele contributed to the radiographic features in 44% of patients with rheumatoid arthritis and associated HLA-B27. Thus, the wide range of findings in our population indicates that the radiographic attributes are not specific enough to constitute a unique subpopulation of patients with rheumatoid arthritis.
对一组9名经典血清阳性类风湿性关节炎患者的X光片进行了复查，这些患者经组织分型发现表达I类HLA - B27等位基因。对X光片进行了分析，看其是否显示出以下影像学特征：(1) 经典类风湿性关节炎，(2) 血清阴性关节炎，或(3) 类风湿性和血清阴性关节炎的混合特征。5名患者(55%)显示出与类风湿性关节炎诊断相符的影像学特征，2名患者(22%)表现出血清阴性疾病的影像学特征(骨膜炎和骶髂关节炎)，2名患者(22%)呈现出类风湿性关节炎和血清阴性疾病的混合表现。因此，HLA - B27等位基因在44%的类风湿性关节炎及相关HLA - B27患者的影像学特征中起作用。因此，我们研究人群中的广泛发现表明，影像学特征不够特异，不足以构成类风湿性关节炎患者的一个独特亚群。
