Nardiello S, Russo M, Pizzella T, Galanti B
J Clin Lab Immunol. 1983 Aug;11(4):177-80.
Adenosine deaminase (ADA) activity was measured in peripheral blood mononuclear cells (PBMC) from patients with chronic liver disease (CLD). Mean ADA levels were decreased in patients with untreated chronic active hepatitis (CAH). ADA levels in patients with CAH in remission under immunosuppressive treatment and in patients with inactive cirrhosis (IC) were similar to control values. ADA levels were not related to any of the biochemical parameters examined, or to the percentage of T cells evaluated on the same PBMC preparations. Our data suggest that biochemical and/or histological remission in CLD may be associated with normalization of ADA levels in PBMC.
在慢性肝病（CLD）患者的外周血单个核细胞（PBMC）中检测了腺苷脱氨酶（ADA）活性。未经治疗的慢性活动性肝炎（CAH）患者的ADA平均水平降低。接受免疫抑制治疗处于缓解期的CAH患者和非活动性肝硬化（IC）患者的ADA水平与对照值相似。ADA水平与所检测的任何生化参数均无关，也与在相同PBMC制剂上评估的T细胞百分比无关。我们的数据表明，CLD中的生化和/或组织学缓解可能与PBMC中ADA水平的正常化有关。
