Nilius R, Neef L, Rath F W, Gatzsche M, Zipprich B
Klinik und Poliklinik für Innere Medizin I.
Dtsch Z Verdau Stoffwechselkr. 1987;47(5):224-9.
Inflammatory liver diseases display higher levels in serum ADA activity compared to non-inflammatory ones. The most pronounced increases in activity are found in acute virus-induced hepatitis, in active liver cirrhoses, extremely high levels in some liver tumours. Due to correlative relations, the ADA is mainly attributed to the mesenchymal parameters by factor analysis. This can be validated by assessment of histological criteria. The highest correlation coefficient could be demonstrated for ADA in relation to all parameters under investigation by means of the semi-quantitatively evaluated mesenchymal reaction within the histological section. The determination of the serum ADA is valuable in assessing the inflammatory reaction of the liver and for diagnosing active cirrhosis in particular. Increases in activity based on an elevated nucleic acid metabolism in tumours and regenerative processes have to be taken into consideration. This interpretation is evidenced by correlative relations between the activity of ADA in liver biopsy homogenate specimen and the hepatic inflammatory reaction.
与非炎症性肝病相比，炎症性肝病血清腺苷脱氨酶（ADA）活性水平更高。活性增加最为显著的是急性病毒感染性肝炎、活动性肝硬化，在某些肝肿瘤中ADA水平极高。由于存在相关性，通过因子分析，ADA主要归因于间充质参数。这可通过组织学标准评估来验证。通过对组织学切片中间充质反应进行半定量评估，ADA与所有研究参数之间的相关性系数最高。血清ADA的测定对于评估肝脏的炎症反应尤其是诊断活动性肝硬化具有重要价值。必须考虑到肿瘤和再生过程中因核酸代谢升高导致的活性增加。肝活检匀浆标本中ADA活性与肝脏炎症反应之间的相关性证明了这一解释。
