Turner R R, Egbert P, Warnke R A
Am J Clin Pathol. 1984 Apr;81(4):447-52. doi: 10.1093/ajcp/81.4.447.
The authors have performed frozen section immunologic stains on 16 cases of ocular lymphocytic infiltrates and correlated the results with clinical and histologic findings. Their cases included inflammatory pseudotumor (3), reactive lymphoid hyperplasia (3), atypical lymphocytic infiltrate (9), and small cleaved cell lymphoma (1). Seven of the nine cases with an atypical lymphocytic infiltrate expressed one immunoglobulin light chain, while only one of six considered reactive on histologic evaluation had immunologic results suggestive of a neoplastic B cell proliferation. The case of follicular small cleaved cell lymphoma expressed B lineage antigens but did not express immunoglobulin; this patient died of disseminated lymphoma two years after conjunctival involvement. Percentages and subset ratios of T lymphocytes were quantitated and showed similar results in reactive and neoplastic lesions. There is no apparent difference in clinical presentation or follow-up information between patients with reactive lesions and those having an atypical lymphocytic infiltrate with monotypic immunoglobulin.
作者对16例眼部淋巴细胞浸润病例进行了冰冻切片免疫染色，并将结果与临床和组织学发现进行了关联。他们的病例包括炎性假瘤（3例）、反应性淋巴样增生（3例）、非典型淋巴细胞浸润（9例）和小裂细胞淋巴瘤（1例）。9例非典型淋巴细胞浸润病例中有7例表达一种免疫球蛋白轻链，而在组织学评估中被认为是反应性的6例病例中只有1例免疫结果提示肿瘤性B细胞增殖。滤泡性小裂细胞淋巴瘤病例表达B谱系抗原，但不表达免疫球蛋白；该患者在结膜受累两年后死于播散性淋巴瘤。对T淋巴细胞的百分比和亚群比例进行了定量分析，结果显示反应性病变和肿瘤性病变相似。反应性病变患者与具有单型免疫球蛋白的非典型淋巴细胞浸润患者在临床表现或随访信息方面没有明显差异。
