Wolfe J A, Borowitz M J
Am J Clin Pathol. 1984 Apr;81(4):526-9. doi: 10.1093/ajcp/81.4.526.
The authors recently have encountered a unique case of composite lymphoma arising in a 69-year-old man with severe long-standing rheumatoid arthritis. The neoplasm was composed of two B-cell lymphomas occurring within a single axillary lymph node: nodules of IgG-kappa nodular poorly differentiated lymphocytic lymphoma were surrounded by a diffuse growth of IgM-lambda well-differentiated lymphocytic lymphoma. It was the immunohistologic studies performed in this case that demonstrated the simultaneous occurrence of two separate monoclonal lymphocyte proliferations. Without the immunohistologic procedures, this composite lymphoma easily may have been overlooked. This unusual malignancy arose in the background of a long-standing autoimmune disease that may have played a role in its genesis.
作者最近遇到了一例独特的复合性淋巴瘤病例，该病例发生在一名患有严重长期类风湿性关节炎的69岁男性身上。肿瘤由单个腋窝淋巴结内出现的两种B细胞淋巴瘤组成：IgG-κ结节性低分化淋巴细胞淋巴瘤的结节被IgM-λ高分化淋巴细胞淋巴瘤的弥漫性生长所包围。正是在该病例中进行的免疫组织学研究证实了两种独立的单克隆淋巴细胞增殖同时存在。如果没有免疫组织学检查程序，这种复合性淋巴瘤很可能会被忽视。这种不寻常的恶性肿瘤发生在一种长期自身免疫性疾病的背景下，这种疾病可能在其发生过程中起到了一定作用。
