Dark A J, Proctor J
Br J Ophthalmol. 1983 Dec;67(12):799-803. doi: 10.1136/bjo.67.12.799.
Flecks consisting of brilliant reflective blue dots and streaks were a prominent biomicroscopical feature in three patients with Cogan's microcystic corneal dystrophy. Two patients required epithelial debridement. We used the material obtained to investigate their histology and ultrastructure. A subepithelial accumulation of basement membrane-like material composed of ultrastructurally fine granules was deposited in alternating layers of compaction and rarefaction. The layers lie mostly parallel to the anterior corneal surface, but in some places they are folded. Such foldings are possibly the sites of multilaminar reflection and constructive interference, giving rise to the blue iridescence.
在3例科根微囊性角膜营养不良患者中，由明亮的反射性蓝点和条纹组成的斑点是显著的生物显微镜特征。2例患者需要进行上皮清创术。我们利用所获得的材料研究其组织学和超微结构。由超微结构精细颗粒组成的基底膜样物质在致密层和疏松层交替沉积，形成上皮下积聚。这些层大多与角膜前表面平行，但在某些地方会折叠。这种折叠可能是多层反射和相长干涉的部位，从而产生蓝色虹彩。
