Dark A J
Br J Ophthalmol. 1978 Dec;62(12):821-30. doi: 10.1136/bjo.62.12.821.
Corneal biopsy specimens from 3 patients with Cogan's microcystic corneal dystrophy were examined by light and electron microscopy. Specimens were taken from corneas showing microcysts, geographic or map-like areas, and refractile striae. In all samples there is a bilaminate subepithelial layer of fibrogranular material, the friability of which is probably the basis for recurrent erosions in this disorder. Histochemical and ultrastructural findings provide further evidence that Cogan's dystrophy, the finger print/bleb dystrophy, and Meesmann's dystrophy should be regarded as separate entities.
对3例患有科根微囊状角膜营养不良的患者的角膜活检标本进行了光镜和电镜检查。标本取自显示微囊肿、地图状或地图样区域以及折光性条纹的角膜。在所有样本中，均有一层由纤维颗粒物质构成的双层上皮下层，其易碎性可能是该疾病反复发生角膜糜烂的基础。组织化学和超微结构研究结果进一步证明，科根营养不良、指纹/疱状营养不良和米斯曼营养不良应被视为不同的疾病实体。
