Ohlsén L, Widenfalk B
Scand J Plast Reconstr Surg. 1983;17(3):163-77. doi: 10.3109/02844318309013114.
In an experimental series of 39 rabbits the articular cartilage of the femur condyles was resected and the defect covered by a perichondrial graft from rib cartilage. The graft was fixed to the bony surface by using Tisseal (Immuno AG) and the joint was immobilized for two weeks. Beginning 24 hours postoperatively the neochondrogenesis from the perichondrial graft was analyzed histologically, sacrificing the rabbits with 48 hours interval. The fibrin glue acted as a visible border line between the bony surface and the graft. No vascular proliferations penetrated the fibrin glue, indicating that the perichondrial graft must be nourished by the synovial fluid only. The neochondrogenesis was found to occur in the median and fibrous layer of the graft.
在一组对39只兔子进行的实验中，切除股骨髁的关节软骨，并用来自肋软骨的软骨膜移植物覆盖缺损处。使用纤维蛋白胶（Immuno AG公司生产）将移植物固定于骨表面，关节固定两周。术后24小时开始，每隔48小时处死兔子，对软骨膜移植物的新软骨形成进行组织学分析。纤维蛋白胶在骨表面和移植物之间形成了一条可见的边界线。没有血管增生穿透纤维蛋白胶，这表明软骨膜移植物必须仅由滑液提供营养。新软骨形成发生在移植物的中间层和纤维层。
