Bolotovskiĭ V M, Gelikman B G, Slavnitskaia I V, Glinskaia E V, Auzinia A V
Zh Mikrobiol Epidemiol Immunobiol. 1984 Feb(2):83-7.
The mass serological survey of school children immunized against measles was carried out by means of the hemagglutination inhibition test. As a result, 20.4% of these school children were found to be seronegative, and in 9.5% of them even the minimum concentration of measles antihemagglutinins (when titrated with 1 hemagglutinating unit of the antigen) was not detected. The accumulation of a considerable seronegative (measles-susceptible) stratum among children of school age occurred due to the low immunogenic potency of some batches of live measles vaccine, used for immunization in 1973, as well as due to the formerly practiced immunization of children under 1 year of age. A direct and close dependence of focal measles morbidity among immunized children having had contacts with the source of infection on the number of children among them, found to be seronegative after titration with 1 hemagglutination unit of measles antigen, was established.
采用血凝抑制试验对已接种麻疹疫苗的学龄儿童进行了大规模血清学调查。结果发现,这些学龄儿童中有20.4%的人血清学呈阴性,其中9.5%的人甚至未检测到麻疹抗血凝素的最低浓度(用1个血凝单位的抗原进行滴定)。1973年用于免疫接种的部分批次活麻疹疫苗免疫原性较低,以及以前对1岁以下儿童进行免疫接种,导致学龄儿童中出现了相当数量的血清学阴性(对麻疹易感)人群。已确定,在与传染源有接触的已接种疫苗儿童中,局部麻疹发病率与在用1个麻疹抗原血凝单位滴定后血清学呈阴性的儿童数量之间存在直接且密切的相关性。