Ikushima T, Benz R D, Carsten A L
Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Mar;45(3):251-6. doi: 10.1080/09553008414550351.
The ability of tritium to induce sister chromatid exchanges (SCEs) has been investigated in male mice of the Hale-Stoner-Brookhaven strain maintained on drinking water containing 3.0 microCi/ml tritiated water (HTO). At selected intervals after 28-261 days of consuming HTO, the frequency of SCEs and the kinetics of cellular proliferation were measured in bone marrow cells of animals maintained on HTO, and in age-matched control groups, by 5-bromo-2'-deoxyuridine labelling methods. A statistically significant (1 percent level) elevation of SCEs was observed after 81, 163, 192, 247 and 261 days of HTO ingestion. The frequency of induced SCEs increased linearly with the ingestion time. These results are of particular interest since ionizing radiation is generally not considered to be an efficient inducer of SCEs.
在饮用含3.0微居里/毫升氚水（HTO）的饮用水的黑尔-斯通纳-布鲁克海文品系雄性小鼠中，研究了氚诱导姐妹染色单体交换（SCEs）的能力。在摄入HTO 28至261天后的选定时间间隔，通过5-溴-2'-脱氧尿苷标记法，测量摄入HTO的动物以及年龄匹配的对照组动物骨髓细胞中SCEs的频率和细胞增殖动力学。在摄入HTO 81、163、192、247和261天后，观察到SCEs有统计学显著升高（1%水平）。诱导的SCEs频率随摄入时间呈线性增加。这些结果特别令人关注，因为电离辐射通常不被认为是SCEs的有效诱导剂。
