Morimoto K, Koizumi A
Environ Res. 1983 Oct;32(1):72-9. doi: 10.1016/0013-9351(83)90193-7.
The four major trihalomethanes (THMs) found in chlorinated drinking water (CHCl3, CHCl2Br, CHClBr2, and CHBr3) have been investigated for their ability to induce sister chromatid exchanges (SCEs) and cell-cycle delays in human lymphocytes in vitro and to induce SCEs in mouse bone marrow cells in vivo. Each THM tested caused dose-dependent increases in SCE frequency and delays in the cell cycle. The THMs differed greatly in their ability to induce these cytological effects in vitro, with CHBr3 being the most active compound and CHCl3 the least active compound, whereas they were not markedly different in their ability to induce SCEs in vivo.
对氯化饮用水中发现的四种主要三卤甲烷（三氯甲烷、二氯一溴甲烷、一氯二溴甲烷和三溴甲烷）进行了研究，考察它们在体外诱导人淋巴细胞姐妹染色单体交换（SCEs）和细胞周期延迟以及在体内诱导小鼠骨髓细胞SCEs的能力。所测试的每种三卤甲烷均导致SCE频率呈剂量依赖性增加以及细胞周期延迟。这些三卤甲烷在体外诱导这些细胞学效应的能力上差异很大，其中三溴甲烷是最具活性的化合物，而三氯甲烷是活性最低的化合物，然而它们在体内诱导SCEs的能力上没有明显差异。
