Fritzler M J, Arlette J P, Behm A R, Kinsella T D
J Am Acad Dermatol. 1984 Feb;10(2 Pt 1):192-6. doi: 10.1016/s0190-9622(84)70022-3.
Because the telangiectasia of hereditary hemorrhagic telangiectasia (HHT) and the CREST variant of scleroderma may be indistinguishable, we have tested the sera of eight patients with HHT for the presence of antinuclear (ANA) and anticentromere antibodies (ACA). In contrast to patients with the CREST syndrome, none of the sera of patients with HHT had elevated levels of ANA and a search for ACA was negative. Therefore, the presence of ACA may help differentiate the patient with CREST from the patient with HHT.
由于遗传性出血性毛细血管扩张症（HHT）的毛细血管扩张与硬皮病的CREST变异型可能难以区分，我们检测了8例HHT患者血清中的抗核抗体（ANA）和抗着丝点抗体（ACA）。与CREST综合征患者不同，HHT患者的血清中ANA水平均未升高，且ACA检测结果为阴性。因此，ACA的存在可能有助于区分CREST患者和HHT患者。
