Abe T, Takeuchi T, Kiyotaki M, Koide J, Hosono O, Homma M, Otake T, Kano S
J Immunol. 1984 May;132(5):2381-5.
A 51-yr-old Japanese female patient with monoclonal IgM gammopathy with rheumatoid factor activity was admitted because of pneumococcal bacteremia. About 2 wk after admission, her rheumatoid factor activity became undetectable by RAHA test and radioimmunoassay, subsequent to the initial marked elevation. The suppressive capacity of the patient's IgG fraction on the rheumatoid activity of her monoclonal IgM on January 11 was determined. The IgG fraction obtained on February 22 blocked the binding of the rheumatoid factor to rabbit IgG. The suppressive activity in the IgG fraction of February 22 was shown to be localized within the F(ab')2 fragment. Furthermore, the specificity of the suppressive serum factor was shown by the inability to block the binding of SRBC coupled with diazotized phosphorylcholine to anti-pneumococcal antibody. Thus, the marked reduction of rheumatoid factor activity was considered to result from anti-idiotypic antibody transiently appearing in her serum after pneumococcal bacteremia.
一名51岁患有具有类风湿因子活性的单克隆IgM丙种球蛋白病的日本女性患者因肺炎球菌菌血症入院。入院约2周后，在最初显著升高之后，通过类风湿因子血凝试验（RAHA test）和放射免疫测定法检测不到她的类风湿因子活性。测定了1月11日患者IgG组分对其单克隆IgM类风湿活性的抑制能力。2月22日获得的IgG组分阻断了类风湿因子与兔IgG的结合。2月22日IgG组分中的抑制活性显示定位于F(ab')2片段内。此外，抑制性血清因子的特异性表现为不能阻断偶联重氮化磷酰胆碱的绵羊红细胞（SRBC）与抗肺炎球菌抗体的结合。因此，类风湿因子活性的显著降低被认为是肺炎球菌菌血症后患者血清中短暂出现的抗独特型抗体所致。
