独特型网络：类风湿关节炎患者血清阴性的可能解释。
Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.
作者信息
Pasquali J L, Urlacher A, Storck D
出版信息
Clin Exp Immunol. 1984 Feb;55(2):281-6.
Abstract
In order to explain long term seronegativity in certain patients with rheumatoid arthritis (RA), we looked for the presence of anti-idiotypic antibodies against rheumatoid factors (RFs). From a patient's serum with classical but seronegative RA, we isolated a low quantity of the IgG fraction which partially recognized polyclonal RF idiotypes. The purified Fab'2 anti-idiotypic antibodies were able to inhibit up to 48% of in vitro RF production by pokeweed mitogen stimulated lymphocytes from a patient's peripheral blood with seropositive RA. The two main conclusions of this study are: (1) this single patient with seronegative RA has serum antibodies directed against RF idiotypes and (2) these anti-idiotypic antibodies could be implicated in the generation of seronegativity.
摘要
为了解释某些类风湿关节炎（RA）患者的长期血清学阴性情况，我们探寻了抗类风湿因子（RF）独特型抗体的存在。从一名患有典型血清学阴性RA的患者血清中，我们分离出少量IgG组分，其能部分识别多克隆RF独特型。纯化的Fab'2抗独特型抗体能够抑制来自一名血清学阳性RA患者外周血的商陆有丝分裂原刺激淋巴细胞体外产生RF的能力，抑制率高达48%。本研究的两个主要结论是：（1）这名血清学阴性RA患者的血清中有针对RF独特型的抗体；（2）这些抗独特型抗体可能与血清学阴性的产生有关。
相似文献
1
Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.独特型网络：类风湿关节炎患者血清阴性的可能解释。
Clin Exp Immunol. 1984 Feb;55(2):281-6.
2
3
A monoclonal anti-idiotype specific for human polyclonal IgM rheumatoid factor.一种针对人多克隆IgM类风湿因子的单克隆抗独特型抗体。
J Immunol. 1992 Jun 15;148(12):3873-8.
4
The internal image of IgG in cross-reactive anti-idiotypic antibodies against human rheumatoid factors.针对人类类风湿因子的交叉反应性抗独特型抗体中IgG的内部影像。
J Immunol. 1983 Aug;131(2):719-24.
5
A highly conserved determinant on human rheumatoid factor idiotypes defined by a mouse monoclonal antibody.一种由小鼠单克隆抗体所定义的人类类风湿因子独特型上的高度保守决定簇。
Eur J Immunol. 1983 Mar;13(3):197-201. doi: 10.1002/eji.1830130304.
6
7
Suppression of rheumatoid factor synthesis by antiidiotypic antibody in rheumatoid arthritis patients with cross-reactive idiotypes.具有交叉反应性独特型的类风湿关节炎患者中抗独特型抗体对类风湿因子合成的抑制作用
Arthritis Rheum. 1985 Aug;28(8):873-81. doi: 10.1002/art.1780280806.
8
Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester.天冬甜素（一种二肽甲酯）对类风湿因子活性的干扰。
J Mol Recognit. 1999 Jul-Aug;12(4):249-57. doi: 10.1002/(SICI)1099-1352(199907/08)12:4<249::AID-JMR463>3.0.CO;2-B.
9
10
Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester.二肽甲酯阿斯巴甜对类风湿因子活性的干扰。
J Mol Recognit. 1999 Sep-Oct;12(5):249-57.
引用本文的文献
1
Differences in anti-Fab antibodies in adult and late onset rheumatoid arthritis.成人及迟发性类风湿关节炎中抗Fab抗体的差异。
Rheumatol Int. 1993;13(3):107-12. doi: 10.1007/BF00290297.
2
An idiotypic complementarity between rheumatoid factor and anti-peptidoglycan antibodies?类风湿因子与抗肽聚糖抗体之间的独特型互补性？
Clin Exp Immunol. 1985 Aug;61(2):373-8.
3
Spontaneous reversal of acquired autoimmune dysfibrinogenemia probably due to an antiidiotypic antibody directed to an interspecies cross-reactive idiotype expressed on antifibrinogen antibodies.获得性自身免疫性异常纤维蛋白原血症的自发缓解可能是由于一种抗独特型抗体，该抗体针对抗纤维蛋白原抗体上表达的种间交叉反应独特型。
J Clin Invest. 1988 Sep;82(3):958-63. doi: 10.1172/JCI113704.
4
Heterogeneity of anti-idiotypic antibodies to anti-DNA antibodies in humans.人类抗DNA抗体的抗独特型抗体的异质性。
Clin Exp Immunol. 1988 Jan;71(1):67-72.
5
Anti-idiotypic induced suppression of Sjögren's syndrome associated anti-La autoantibody secretion in vitro.抗独特型抗体体外诱导抑制干燥综合征相关抗La自身抗体的分泌
Clin Exp Immunol. 1988 Jan;71(1):62-6.
6
Idiotypes and the structural diversity of human rheumatoid factors.独特型与人类类风湿因子的结构多样性
Springer Semin Immunopathol. 1988;10(2-3):189-201. doi: 10.1007/BF01857224.
7
The specificity of human autoantibodies to IgG: the development of methodology for measuring the specificity of antiglobulin isotypes in rheumatoid and normal sera.人自身抗体对IgG的特异性：类风湿性和正常血清中抗球蛋白同种型特异性检测方法的发展
Rheumatol Int. 1986;6(4):155-60. doi: 10.1007/BF00541282.
8
The idiotype-antiidiotype network in human autoimmunity.人类自身免疫中的独特型-抗独特型网络。
J Clin Immunol. 1985 Nov;5(6):365-9. doi: 10.1007/BF00915332.
9
10
Monoclonal antibodies defining a minor and a private idiotope on human rheumatoid factors.定义人类类风湿因子上一个次要独特型和一个个体独特型的单克隆抗体。
J Clin Immunol. 1986 Sep;6(5):349-54. doi: 10.1007/BF00915373.
本文引用的文献
1
Inheritance of immunoglobulin M rheumatoid-factor idiotypes.免疫球蛋白M类风湿因子独特型的遗传
J Clin Invest. 1980 Oct;66(4):863-6. doi: 10.1172/JCI109927.
2
3
Cellular localization of rheumatoid factor idiotypes.类风湿因子独特型的细胞定位。
J Clin Invest. 1982 Jun;69(6):1356-65. doi: 10.1172/jci110575.
4
Naturally occurring autologous anti-idiotypic antibodies. Participation in immune complex formation in selective IgA deficiency.天然存在的自体抗独特型抗体。在选择性IgA缺乏症中参与免疫复合物形成。
J Exp Med. 1982 Mar 1;155(3):711-9. doi: 10.1084/jem.155.3.711.
5
Selective lymphocyte deficiency in seronegative rheumatoid arthritis.血清阴性类风湿关节炎中的选择性淋巴细胞缺乏症。
Arthritis Rheum. 1981 Jun;24(6):770-3. doi: 10.1002/art.1780240603.
6
Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus.自身免疫中的网络理论。系统性红斑狼疮中抗独特型抗体对血清抗DNA抗体与DNA结合的体外抑制作用。
J Clin Invest. 1981 May;67(5):1297-304. doi: 10.1172/jci110158.
7
Cellular requirements for pokeweed mitogen-induced autoantibody production rheumatoid arthritis.商陆有丝分裂原诱导自身抗体产生在类风湿关节炎中的细胞需求
J Immunol. 1980 Sep;125(3):1125-9.
8
Antiidiotypic activity in the IgM fractions of mixed cryoglobulins.混合冷球蛋白IgM组分中的抗独特型活性。
J Immunol. 1980 Oct;125(4):1530-5.
9
Regulation of monoclonal immunoglobulin G synthesis by antiidiotypic antibody in a patient with hypogammaglobulinemia.抗独特型抗体对低丙种球蛋白血症患者单克隆免疫球蛋白G合成的调节
J Clin Invest. 1980 May;65(5):1202-9. doi: 10.1172/JCI109775.
10
The immunopathology of joint inflammation in rheumatoid arthritis.类风湿关节炎中关节炎症的免疫病理学
Adv Immunol. 1973;16(0):265-336. doi: 10.1016/s0065-2776(08)60299-0.
Zotero 插件