胎儿脑积水。二、非人灵长类动物宫内治疗对胎儿孔洞脑的改善作用。

Fetal hydrocephalus. II. Amelioration of fetal porencephaly by in utero therapy in nonhuman primates.

作者信息

Michejda M, Patronas N, Di Chiro G, Hodgen G D

出版信息

JAMA. 1984 May 18;251(19):2548-52. doi: 10.1001/jama.251.19.2548.

DOI:10.1001/jama.251.19.2548

Abstract

The postnatal course of a form of infantile porencephaly under pressure in monkeys was evaluated by comparing brain development between animals that had received the hydrocephalic antenatal vent for intrauterine treatment and those that had not been treated antenatally. Brain development was assessed by computed tomographic scans. The studies showed asymmetric malformations and associated porencephalic lesions in infant monkeys not treated in utero, despite installation of a conventional postnatal ventriculoperitoneal shunt. In contrast, apparently normal development of brain tissue in infants given intrauterine therapy was observed.

摘要

通过比较接受宫内治疗的脑积水产前引流的猴子与未接受产前治疗的猴子之间的大脑发育情况，评估了一种受压型婴儿孔洞脑的产后病程。通过计算机断层扫描评估大脑发育情况。研究表明，尽管安装了传统的产后脑室腹腔分流术，但未在子宫内接受治疗的幼猴仍存在不对称畸形及相关的孔洞脑病变。相比之下，观察到接受宫内治疗的婴儿脑组织发育明显正常。