Elovaara E, Pfäffli P, Savolainen H
Acta Pharmacol Toxicol (Copenh). 1984 Mar;54(3):221-6. doi: 10.1111/j.1600-0773.1984.tb01921.x.
Adult male rats exposed to tetrahydrofuran vapour at 8.2 (200 p.p.m.), 41 (1,000 p.p.m.) or 82 mumol/l (2,000 p.p.m.) for 2 to 18 weeks, five days a week, 6 hrs daily, showed dose-dependent brain and perirenal fat solvent burden linearly correlated to each other. After two weeks of exposure, the body burden of tetrahydrofuran seems to decrease. This might have been caused by increased oxidative metabolism as enhanced 7-ethoxycoumarin O-deethylase activity was detected in liver and kidneys in the 2nd week and onwards. The exposure also caused inhibition of alcohol and formaldehyde dehydrogenase activities in liver at the highest dose. Biochemical effects in the cerebellum were not detected while gluteal muscle specimens showed increased succinate dehydrogenase activity in a dose-related manner. This points to effects on the energy metabolism. Muscle acetylcholine esterase activity was also increased showing possible effects on the myoneural junctions.
成年雄性大鼠每周五天、每天6小时暴露于浓度为8.2（200 ppm）、41（1000 ppm）或82 μmol/L（2000 ppm）的四氢呋喃蒸气中2至18周，结果显示大脑和肾周脂肪中的溶剂负荷呈剂量依赖性，且二者呈线性相关。暴露两周后，四氢呋喃的体内负荷似乎有所下降。这可能是由于氧化代谢增强所致，因为在第2周及之后，肝脏和肾脏中检测到7-乙氧基香豆素O-脱乙基酶活性增强。最高剂量的暴露还导致肝脏中酒精和甲醛脱氢酶活性受到抑制。未检测到小脑的生化效应，而臀肌标本显示琥珀酸脱氢酶活性呈剂量相关增加。这表明对能量代谢有影响。肌肉乙酰胆碱酯酶活性也增加，表明可能对肌神经接头有影响。
