Giarcovich S, Enero M A
Eur J Pharmacol. 1984 Apr 13;100(1):123-5. doi: 10.1016/0014-2999(84)90325-x.
Acute propranolol reduced the synthesis rate of serotonin in several rat brain structures (hypothalamus, midbrain, pons, frontal cortex and medulla oblongata). Both optical isomers of propranolol were tested. From our results it may be concluded that both the beta-blocking property and the local anaesthetic action of the drug could be involved in its inhibitory effect, except in hypothalamus where only the levorotating isomer was effective. Our results suggest the possibility of a noradrenergic influence on brain serotonergic neurons.
急性给予普萘洛尔可降低大鼠多个脑区（下丘脑、中脑、脑桥、额叶皮质和延髓）中血清素的合成速率。对普萘洛尔的两种光学异构体均进行了测试。从我们的结果可以得出结论，该药物的β受体阻断特性和局部麻醉作用可能都参与了其抑制作用，但在下丘脑中只有左旋异构体有效。我们的结果提示了去甲肾上腺素能对脑血清素能神经元产生影响的可能性。
