长期给予大鼠甲基苯丙胺后大脑血清素合成速率的降低。
Reduction in brain serotonin synthesis rate following chronic methamphetamine administration in rats.
作者信息
Trulson M E, Trulson V M
出版信息
Eur J Pharmacol. 1982 Sep 10;83(1-2):97-100. doi: 10.1016/0014-2999(82)90290-4.
Chronic administration of methamphetamine (20 mg/kg i.p., every 12 h for 6 days) produced significant decreased in brain 5-hydroxytryptophan accumulation following decarboxylase inhibition and 5-hydroxyindoleacetic acid accumulation following probenecid treatment in rats. Administration of fluoxetine prior to each methamphetamine injection prevented these neurochemical changes. Acute methamphetamine treatment produced no changes in these neurochemical measures. These data demonstrate that chronic, but not acute, methamphetamine treatment reduces brain serotonin synthesis rate.
对大鼠进行甲基苯丙胺慢性给药（腹腔注射20毫克/千克，每12小时一次，共6天）后，在抑制脱羧酶后，脑内5-羟色氨酸蓄积显著减少，在丙磺舒处理后，5-羟吲哚乙酸蓄积也显著减少。在每次注射甲基苯丙胺之前给予氟西汀可防止这些神经化学变化。急性甲基苯丙胺处理对这些神经化学指标没有影响。这些数据表明，慢性而非急性的甲基苯丙胺处理会降低脑内血清素合成速率。
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