暴露于佛波酯肉豆蔻酸酯乙酸酯后绵羊未成熟B细胞的分化
Differentiation of ovine immature B cells upon exposure to phorbol myristate acetate.
作者信息
Miyasaka M, Dudler L
出版信息
Int Arch Allergy Appl Immunol. 1984;74(3):281-3. doi: 10.1159/000233559.
PMID:6609890
Abstract
Immature B cells obtained from the ileal Peyer's patches ( IPPs ) of sheep, upon exposure to phorbol myristate acetate (PMA), expressed 20-30 times more sIgM per cell than nonstimulated IPP cells, and the sIgM level was the same as that of peripheral B cells. The exposure of IPP cells to PMA also induced IgM secretion. Macrophages were not required for the terminal differentiation of IPP cells in vitro.
摘要
从绵羊回肠派尔集合淋巴结（IPP）获得的未成熟B细胞，在暴露于佛波酯（PMA）后，每个细胞表达的表面免疫球蛋白M（sIgM）比未刺激的IPP细胞多20 - 30倍，且sIgM水平与外周B细胞相同。IPP细胞暴露于PMA也会诱导IgM分泌。体外IPP细胞的终末分化不需要巨噬细胞。
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