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尖锐湿疣患者的胸腺来源淋巴细胞(T细胞)

Thymus derived lymphocytes (T cells) in patients with genital warts.

作者信息

Mohanty K C, Roy R B

出版信息

Br J Vener Dis. 1984 Jun;60(3):186-8. doi: 10.1136/sti.60.3.186.

Abstract

Thymus derived lymphocytes (T cells) were counted in the peripheral blood of 30 patients with genital warts and in 20 healthy controls. The control group was made up of 10 healthy patients with no history of warts and 10 who had been cured of warts for at least 12 months. We found that patients with genital warts had a significantly lower number of T cells despite an adequate number of circulating lymphocytes in the peripheral blood. We therefore suggest that a functional defect of lymphocytes ("dyslymphocytosis") could be the cause of genital warts either in their primary or recurrent form. These abnormal lymphocytes return to their normal function after the disappearance of genital warts.

摘要

对30例尖锐湿疣患者及20名健康对照者的外周血进行胸腺来源淋巴细胞(T细胞)计数。对照组由10名无疣病史的健康患者和10名已治愈疣至少12个月的患者组成。我们发现,尽管外周血中循环淋巴细胞数量充足,但尖锐湿疣患者的T细胞数量显著较低。因此,我们认为淋巴细胞功能缺陷(“淋巴细胞异常增多症”)可能是尖锐湿疣原发或复发形式的病因。尖锐湿疣消失后,这些异常淋巴细胞恢复正常功能。

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In vitro assay of cell-mediated immunity to human wart antigen.
Br J Dermatol. 1974 May;90(5):531-4. doi: 10.1111/j.1365-2133.1974.tb06448.x.
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