Diehl V, Burrichter H, Schaadt M, Kirchner H H, Fonatsch C, Stein H, Gerdes J, Heit W, Ziegler A
Hematol Oncol. 1983 Apr-Jun;1(2):139-47. doi: 10.1002/hon.2900010204.
In the last four years we established five long term cultures from tumor material of Hodgkin's disease. The in vitro cells have malignant characteristics and represent the in vivo H- and SR-cells. Common immunological, functional and morphological assays did not characterize the in vitro cells to be a known cell type of lymphoid, myeloid or monocytoid tissue. The in vitro Hodgkin cells are biologically active by producing factors involved in regulation and promotion of immunological response and granulopoiesis. The relevance of the findings for pathogenesis and clinical appearance of Hodgkin's disease is discussed.
在过去四年里，我们从霍奇金病的肿瘤材料中建立了五种长期培养物。体外培养的细胞具有恶性特征，代表体内的H细胞和SR细胞。常规的免疫、功能和形态学检测并未将体外培养的细胞鉴定为淋巴、髓样或单核细胞组织的已知细胞类型。体外培养的霍奇金细胞具有生物活性，可产生参与调节和促进免疫反应及粒细胞生成的因子。本文讨论了这些发现与霍奇金病发病机制和临床表现的相关性。
