用氚标记胸腺嘧啶核苷体内标记霍奇金组织的定量细胞学和细胞化学
Quantitative cytology and cytochemistry of Hodgkin's tissue labelled in vivo with tritiated thymidine.
作者信息
Peckham M J
出版信息
Br J Cancer. 1973 Oct;28(4):332-9. doi: 10.1038/bjc.1973.156.
The cellular composition of Hodgkin's tissue from two patients has been examined. The labelling pattern with (3)H-TdR has been studied on in vivo labelled imprints and histological sections. The relative proportions of the various classes of cells are maintained when Hodgkin's tissue increases in bulk. Histological progression from LP/MC to MC Hodgkin's disease was associated with an increase in aneuploidy of the Hodgkin cell line and an increase in the proportion of large basophilic blast cells. Splenic Hodgkin's disease in the same patient contained fewer aneuploid cells. The significance of these findings in terms of the histogenesis of Hodgkin and Sternberg-Reed cells is discussed.
对两名患者的霍奇金组织的细胞组成进行了检查。利用（3）H-TdR的标记模式已在体内标记的压片和组织切片上进行了研究。当霍奇金组织体积增大时，各类细胞的相对比例保持不变。从淋巴细胞为主型/混合细胞型到混合细胞型霍奇金病的组织学进展与霍奇金细胞系非整倍体增加以及大嗜碱性母细胞比例增加有关。同一患者的脾脏霍奇金病含有的非整倍体细胞较少。讨论了这些发现对于霍奇金细胞和施特恩伯格-里德细胞组织发生学的意义。
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