Morgan K G, Quirke P, O'Brien C J, Bird C C
Department of Pathology, University of Leeds.
J Clin Pathol. 1988 Apr;41(4):365-9. doi: 10.1136/jcp.41.4.365.
Flow cytometry was performed on paraffin embedded tissue from 115 cases of Hodgkin's disease. Thirteen (11%) tumours were aneuploid with no significant difference between the histological subgroups. The median proliferative index was 14%, and the highest values were found in the NS2 (16.4%) and lymphocyte depleted (16.0%) subgroups. The difference in proliferative index approached significance when the NS2 subgroup was compared with the NS1 subgroup (p less than or equal to 0.11) and when the lymphocyte depleted and NS2 subgroups combined were compared with the mixed cellularity, lymphocyte predominance, and NS1 subgroups combined (p less than or equal to 0.07). There was a trend towards better survival for patients with aneuploid tumours and those cases with a proliferative index below 15%, but neither of these trends was significant.
对115例霍奇金病石蜡包埋组织进行了流式细胞术检测。13例（11%）肿瘤为非整倍体，各组织学亚组之间无显著差异。增殖指数中位数为14%，在NS2亚组（16.4%）和淋巴细胞消减亚组（16.0%）中值最高。当NS2亚组与NS1亚组比较时（p≤0.11），以及当淋巴细胞消减亚组和NS2亚组合并与混合细胞型、淋巴细胞为主型和NS1亚组合并比较时（p≤0.07），增殖指数差异接近显著。非整倍体肿瘤患者以及增殖指数低于15%的患者有生存更好的趋势，但这两种趋势均不显著。
