Ojima F, Ido T, Takahashi T, Hatazawa J, Ito M, Sasaki H, Yanai M, Aikawa T, Takishima T, Abiko K
Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan.
Ann Nucl Med. 1989 Nov;3(3):143-7. doi: 10.1007/BF03178301.
Fine 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) powder was obtained by adding diethyl ether into a methyl alcohol solution of 18FDG and other sugar as seed. When micronized particles of sodium N-acetyl-neuraminate (Neu5Ac-Na) were used as seed crystals, particles containing 18FDG were obtained and 80% of them were smaller than 10 microns in size. More than 60% of these crystals were 4-6 microns in size. In a preclinical study of forced inhalation in a dog, the 18FDG fine powder was mainly distributed in the trachea. The radioactivity in the trachea then increased once and a gradual decrease followed. The radioactivity was transferred into the blood and radioactivity incorporation into the heart was observed. After a normal volunteer inhaled 18FDG dry powder aerosol, the radioactivity was found in the respiratory tract and the peripheral area of the lung by means of PET. Absorption and in vivo dynamics of the 18FDG were also analysed.
通过向含有 18FDG 和其他糖类作为晶种的甲醇溶液中加入乙醚，得到了精细的 2-脱氧-2-[18F]氟-D-葡萄糖（18FDG）粉末。当使用 N-乙酰神经氨酸钠（Neu5Ac-Na）的微粉化颗粒作为晶种时，获得了含有 18FDG 的颗粒，其中 80%的颗粒尺寸小于 10 微米。这些晶体中超过 60%的尺寸为 4-6 微米。在对狗进行的强制吸入的临床前研究中，18FDG 细粉主要分布在气管中。气管中的放射性随后先增加一次，然后逐渐下降。放射性转移到血液中，并观察到放射性在心脏中的摄取。一名正常志愿者吸入 18FDG 干粉气雾剂后，通过正电子发射断层扫描（PET）在呼吸道和肺周边区域发现了放射性。还分析了 18FDG 的吸收和体内动力学。
