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[供体联合接种灭活层析流感疫苗和吸附葡萄球菌类毒素的免疫效果]

[Immunological effectiveness of the combined vaccination of donors with inactivated chromatographic influenza vaccine and adsorbed staphylococcal anatoxin].

作者信息

Gel'fand A S, Portniagin V F, Lidina P V, Nekipelova G A, Korenev Iu D

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1984 May(5):95-9.

PMID:6611005
Abstract

The influence of combined immunization with inactivated chromatographic vaccine and adsorbed staphylococcal toxoid on the activity of the immune system of volunteer donors has been studied. With the T- to B-cell ratio in the peripheral blood remaining stable, the third injection of staphylococcal toxoid induces a certain suppression of the capacity of lymphocytes for blast transformation in the presence of mitogen and specific antigens. The intensity of the accumulation of anti-alpha-staphylolysin is subject to considerable individual variations and depends on its level prior to immunization. The level of influenza antihemagglutinins remains most stable when the interval between the injection of inactivated chromatographic influenza vaccine and the beginning of immunization with adsorbed staphylococcal toxoid is 3-6 months.

摘要

研究了用灭活层析疫苗和吸附葡萄球菌类毒素联合免疫对志愿供血者免疫系统活性的影响。在外周血中T细胞与B细胞的比例保持稳定的情况下,第三次注射葡萄球菌类毒素会在有丝分裂原和特异性抗原存在时对淋巴细胞的母细胞转化能力产生一定抑制。抗α - 葡萄球菌溶血素的积累强度存在相当大的个体差异,并且取决于免疫前的水平。当灭活层析流感疫苗注射与吸附葡萄球菌类毒素免疫开始之间的间隔为3至6个月时,流感抗血凝素水平保持最稳定。

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