Krutitskaia L I, Zhebrun A B
Zh Mikrobiol Epidemiol Immunobiol. 1996 Mar-Apr(2):44-7.
Regularities in the formation of autoantibodies to human IgA, IgM, IgG and their fragments, such as F(ab')2, Fab, Fc, in donors immunized with influenza vaccine (44 subjects) and staphylococcal toxoid (15 subjects) were studied with regard to the dynamics of specific immune response. After immunization with staphylococcal toxoid autoimmune reactions were registered only in the precipitation tests during 3-5 weeks of observation. In donors immunized with influenza vaccine the induction of isotypically heterogeneous autoimmune reactions was established. These reactions were represented mainly by IgA and IgG autoantibodies to immunoglobulins of different classes and their fragments. The duration of autoimmune reactions registered in this group of donors was specially noteworthy. The levels of autoantibodies to most of the antigens under study remained significantly elevated for 6 months. After immunization with influenza vaccine the presence of direct correlation between the level of specific immune response and the level of autoantibody formation was established.
研究了用流感疫苗（44名受试者）和葡萄球菌类毒素（15名受试者）免疫的供体中，针对人IgA、IgM、IgG及其片段（如F(ab')2、Fab、Fc）的自身抗体形成规律，涉及特异性免疫反应的动态变化。用葡萄球菌类毒素免疫后，仅在观察的3至5周内的沉淀试验中检测到自身免疫反应。在用流感疫苗免疫的供体中，发现诱导了同种型异质性自身免疫反应。这些反应主要表现为针对不同类别的免疫球蛋白及其片段的IgA和IgG自身抗体。该组供体中记录到的自身免疫反应持续时间特别值得注意。所研究的大多数抗原的自身抗体水平在6个月内仍显著升高。在用流感疫苗免疫后，确定了特异性免疫反应水平与自身抗体形成水平之间存在直接相关性。
