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体内产生的针对M位点决定簇的细胞抑制效应细胞。

Cytostatic effector cells generated in vivo against M locus determinants.

作者信息

Matossian-Rogers A, Festenstein H

出版信息

Clin Exp Immunol. 1977 Feb;27(2):335-9.

PMID:66115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540786/
Abstract

Cytostatic effector cells against M-locus (Mls) determinants were generated in mice by immunization with Mls incompatible lymphocytes. A post-labelling assay of 14C-labelled uridine uptake by macrophage targets was employed to meaure the inhibitory activity of the effector cells. Using lymphocytes from Mls pseudocongenic mice to immunize donors of effector cells, it was confirmed that the cytostatic effect was via the Mls determinants expressed on the macrophage targets. Cytotoxic effector cells against M-locus (Mls) determinants were not detected by the cell-mediated lympholysis assay (CML) in a five day mixed lymphocyte culture (MLC) between Mls incompatible lymphocytes. Specificity of cytotoxic cells generated by culturing in vivo preimmunized responder cells and Mls incompatible stimulator lymphocytes did not correlate with the Mls determinant of the stimulator lymphocytes.

摘要

通过用与M位点（Mls）不相容的淋巴细胞免疫，在小鼠体内产生了针对Mls决定簇的细胞生长抑制效应细胞。采用对巨噬细胞靶标摄取14C标记尿苷的标记后测定法来测量效应细胞的抑制活性。利用来自Mls假同基因小鼠的淋巴细胞免疫效应细胞供体，证实细胞生长抑制效应是通过巨噬细胞靶标上表达的Mls决定簇介导的。在Mls不相容淋巴细胞之间进行的为期五天的混合淋巴细胞培养（MLC）中，细胞介导的淋巴细胞溶解试验（CML）未检测到针对M位点（Mls）决定簇的细胞毒性效应细胞。体内预免疫应答细胞与Mls不相容刺激淋巴细胞培养产生的细胞毒性细胞的特异性与刺激淋巴细胞的Mls决定簇不相关。

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本文引用的文献

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Antigenic strength investigated by cell-mediated lympholysis in mice.通过小鼠体内细胞介导的淋巴细胞溶解作用研究抗原强度。
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Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.小鼠体外淋巴细胞同种异体转化（混合淋巴细胞反应）的免疫遗传学和生物学方面
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T cell proliferation in the mixed lymphocyte culture does not necessarily result in the generation of cytotoxic T effector cells.混合淋巴细胞培养中的T细胞增殖不一定会导致细胞毒性T效应细胞的产生。
Eur J Immunol. 1975 Aug;5(8):560-4. doi: 10.1002/eji.1830050811.
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A new alloantigenic system associated with the Mls locus in the mouse.与小鼠Mls基因座相关的一种新的同种抗原系统。
J Immunol. 1976 Mar;116(3):835-41.
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Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.通过M位点和H-2不相容性进行预免疫对小鼠T细胞细胞毒性的修饰。
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The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.主要组织相容性复合体决定了针对次要组织相容性抗原的细胞毒性T细胞的易感性。
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Specific lymphocyte-activating determinants expressed on mouse macrophages.小鼠巨噬细胞上表达的特异性淋巴细胞激活决定簇。
Nature. 1975 May 8;255(5504):155-6. doi: 10.1038/255155a0.

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