通过M位点和H-2不相容性进行预免疫对小鼠T细胞细胞毒性的修饰。
Modification of murine T-cell cytotoxicity by preimmunization with M locus and H-2 incompatibilities.
作者信息
Matossian-Rogers A, Festenstein H
出版信息
J Exp Med. 1976 Feb 1;143(2):456-61. doi: 10.1084/jem.143.2.456.
Abstract
The effect of preimmunization of CBA/H mice with M locus and H-2 incompatible lymphocytes was examined on the in vitro generation of cytotoxic cells to both types of targets. Preimmunization with M locus did not help to generate cytotoxic cells to M-locus targets; however, the anti-H-2 cytotoxicity of M-locus-preimmunized lymphocytes was suppressed between the 6th and 19th day after preimmunization. In contrast, preimmunization with H-2 incompatibility produced an amplified lytic anti-H-2 response. The possible mechanisms are discussed.
摘要
研究了用M位点和H-2不相容淋巴细胞对CBA/H小鼠进行预免疫，对这两种类型靶标的细胞毒性细胞体外生成的影响。用M位点进行预免疫无助于产生针对M位点靶标的细胞毒性细胞；然而，在预免疫后第6天至第19天之间，M位点预免疫淋巴细胞的抗H-2细胞毒性受到抑制。相比之下，用H-2不相容性进行预免疫产生了增强的溶细胞性抗H-2反应。并讨论了可能的机制。
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本文引用的文献
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