Ketiladze E S, Bugaeva N P, Vorozhbieva T E, Savitskiĭ G I
Vopr Virusol. 1983 May-Jun(3):302-6.
The results of studies on hepatitis B markers (HBsAg, anti-HBs, anti-HBc) by highly sensitive methods in 560 patients aged from 15 to 77 years are presented. Three immunologic groups of HB patients were detected. The first group is most numerous (77%), HBsAg is found in the blood of patients in high concentrations by the gel precipitation test. The second group (19%) has a low concentration of HBsAg detectable only by the RIA. The third, smallest (4%), group showed antibodies to HBsAg of IgM class in the blood from the first days of jaundice in the absence of HBsAg. All the 3 groups differed in the regularities of detection of humoral and cellular immunity and in clinical manifestations of the disease in the acute and convalescent periods. The most severe forms of the disease are associated with the early appearance of free anti-HBs in the blood and a significant decrease in the levels of T-lymphocytes which may be used as immunologic markers for prognosis of the disease.
本文呈现了采用高灵敏度方法对560例年龄在15至77岁患者进行乙肝标志物（HBsAg、抗-HBs、抗-HBc）研究的结果。检测出了乙肝患者的三个免疫组。第一组人数最多（77%），通过凝胶沉淀试验在患者血液中发现高浓度的HBsAg。第二组（19%）HBsAg浓度较低，仅通过放射免疫分析可检测到。第三组人数最少（4%），在黄疸出现的第一天起，血液中在无HBsAg的情况下出现IgM类抗-HBs。所有这三组在体液免疫和细胞免疫的检测规律以及疾病急性期和恢复期的临床表现方面均存在差异。疾病最严重的形式与血液中游离抗-HBs的早期出现以及T淋巴细胞水平的显著降低有关，这些可作为疾病预后的免疫标志物。
