Vento S, Rondanelli E G, Ranieri S, O'Brien C J, Williams R, Eddleston A L
Lancet. 1987 Jul 18;2(8551):119-22. doi: 10.1016/s0140-6736(87)92329-4.
Cellular immunity to hepatitis-B-virus (HBV) antigens was followed prospectively in five patients who were identified in the early incubation phase of acute HBV infection, between 30 and 70 days before the onset of liver damage. Cellular immunity to pre-S antigens was the first detectable immune response, appearing 30 days before the first rise in serum aminotransferases in every case. T-cell sensitisation to HBcAg followed, with IgM anti-HBc appearing 10 days later. A cellular immune response to HBsAg was the last to appear, 10 days before the onset of liver damage. These cellular immune responses are the earliest host responses to the virus infection and could be critical in initiating and directing the processes of liver damage and viral clearance.
对5例在急性乙肝病毒（HBV）感染早期潜伏期（肝损伤发作前30至70天）确诊的患者，前瞻性地追踪其对HBV抗原的细胞免疫情况。对前S抗原的细胞免疫是首个可检测到的免疫反应，在每例患者血清转氨酶首次升高前30天出现。随后是对HBcAg的T细胞致敏，10天后出现IgM抗-HBc。对HBsAg的细胞免疫反应最后出现，在肝损伤发作前10天。这些细胞免疫反应是宿主对病毒感染最早的反应，可能在启动和指导肝损伤及病毒清除过程中起关键作用。
