The effect of anti-inflammatory and anti-rheumatic drugs on cell accumulation onto nitrocellulose discs implanted subcutaneously into mice.

Nitrocellulose discs were implanted subcutaneously into mice and cell accumulation measured 96 hours later. Cell accumulation was inhibited by the anti-inflammatory steroids hydrocortisone, dexamethasone and triamcinolone acetonide, but higher doses of the latter two compounds were required than are normally used in rat models of inflammation. Cell accumulation was not inhibited by the cyclo-oxygenase inhibitors naproxen, indomethacin, tolmetin or aspirin, nor by the dual cyclo-oxygenase and lipoxygenase inhibitors BW 755C and benoxaprofen. Anti-rheumatic drugs such as D-penicillamine, dapsone and colchicine and the metal chelator 1,10 phenanthroline were all inactive on cell accumulation in this model.