Higgs G A, Eakins K E, Mugridge K G, Moncada S, Vane J R
Eur J Pharmacol. 1980 Aug 22;66(1):81-6. doi: 10.1016/0014-2999(80)90297-6.
Some non-steroid anti-inflammatory drugs which inhibit arachidonate cyclo-oxygenease have been examined for their effects on leukocyte migration, prostaglandin production and oedema formation in carrageenin-induced inflammation in the rat. At doses which inhibited oedema, all the drugs tested caused a dose-dependent reduction in numbers of leukocytes and prostaglandin concentrations in 24-h inflammatory exudates. At lower doses, indomethacin, aspirin, sodium salicylate, flurbiprofen and phenylbutazone significantly potentiated leukocyte migration by 20-70%. Ibuprofen, naproxen and BW755C reversed the indomethacin-induced increase in leukocyte accumulation. BW755C inhibits the generation of chemotactic lipoxygenase products and it is possible that the effects of all these drugs on leukocyte migration are mediated through the lipoxygenase pathway of arachidonic acid metabolism.
已对一些抑制花生四烯酸环氧化酶的非甾体抗炎药在角叉菜胶诱导的大鼠炎症中对白细胞迁移、前列腺素生成和水肿形成的影响进行了研究。在抑制水肿的剂量下，所有受试药物均使24小时炎性渗出物中的白细胞数量和前列腺素浓度呈剂量依赖性降低。在较低剂量时，吲哚美辛、阿司匹林、水杨酸钠、氟比洛芬和保泰松可使白细胞迁移显著增强20%-70%。布洛芬、萘普生和BW755C可逆转吲哚美辛诱导的白细胞聚集增加。BW755C抑制趋化性脂氧合酶产物的生成，所有这些药物对白细胞迁移的影响可能是通过花生四烯酸代谢的脂氧合酶途径介导的。
