提高缺氧耐受性后毛细胞的噪声损伤（作者译）

[Hair cell noise damage after improved hypoxia tolerance (author's transl)].

作者信息

Berndt H, Kranz D, Wagner H, Gerhardt H J

出版信息

Laryngol Rhinol Otol (Stuttg). 1978 Jun;57(6):520-3.

Abstract

UNLABELLED

Guinea pigs were gradually adapted to a simulated altitude of 10,000 m. The round window microphone potential (RMP) frequency response was measured 24 hours after pure tone exposition (2.7 kHz, 130 dB, 1 hr). The electrophysiologically demonstrable sound induced damage of the organ of Corti of the adapted guinea pigs was significantly smaller than those of the nonadapted (normal) group. Altitude adapted animals: m = 18, Hb: 18.5 +/- 1.8 g%, Hc: 57.3 +/- 4.4+ RMP mean loss: 1.7 +/- 0.8 dB.

CONTROLS

n = 18, Hb: 12.7 +/- 1.8 g%, Hc: 40.5 +/- 1.6%. RMP mean loss: 5.8 +/- 2.4 dB. All differences significant p less than 0.001. The evident possibility to reduce noise induced hair cell damage by means of previous adaptation to high altitude might be explained by the greater hypoxia tolerance and perhaps additional better oxygen supply to the receptor cells.

摘要

未标记

将豚鼠逐渐适应于模拟海拔10000米的环境。在纯音暴露（2.7千赫，130分贝，1小时）24小时后测量圆窗微音器电位（RMP）频率响应。适应环境的豚鼠经电生理学证实的由声音引起的柯蒂氏器损伤明显小于未适应（正常）组。适应海拔环境的动物：m = 18，血红蛋白（Hb）：18.5±1.8克%，血细胞比容（Hc）：57.3±4.4，RMP平均损失：1.7±0.8分贝。