Tsukada Y
Gan To Kagaku Ryoho. 1983 Sep;10(9):2069-76.
An experimental study using antibodies against tumor-associated antigen(s) of various tumor systems in rats and mice is described. Monoclonal antibodies against the variety of tumor systems may be a useful tool for detecting tumor-associated antigen(s) on the cell surface of tumor cells but in case of highly purified antigen, conventional polyclonal antibody having high antibody titer may still be effective for therapeutic application in experimental systems. The conjugate of antibody with anticancer drugs or toxins may be the most effective compound for therapy since the antibody-homing effect will synergistically increase the cytotoxic activity of drugs or toxins against target tumor cells.
本文描述了一项在大鼠和小鼠中使用针对各种肿瘤系统肿瘤相关抗原的抗体的实验研究。针对多种肿瘤系统的单克隆抗体可能是检测肿瘤细胞表面肿瘤相关抗原的有用工具，但在抗原高度纯化的情况下，具有高抗体滴度的传统多克隆抗体在实验系统中仍可能对治疗应用有效。抗体与抗癌药物或毒素的偶联物可能是最有效的治疗化合物，因为抗体归巢效应将协同增加药物或毒素对靶肿瘤细胞的细胞毒活性。
