[Studies on antibodies against rat and mouse tumors: its application to therapy].

An experimental study using antibodies against tumor-associated antigen(s) of various tumor systems in rats and mice is described. Monoclonal antibodies against the variety of tumor systems may be a useful tool for detecting tumor-associated antigen(s) on the cell surface of tumor cells but in case of highly purified antigen, conventional polyclonal antibody having high antibody titer may still be effective for therapeutic application in experimental systems. The conjugate of antibody with anticancer drugs or toxins may be the most effective compound for therapy since the antibody-homing effect will synergistically increase the cytotoxic activity of drugs or toxins against target tumor cells.