Economou J S
Surg Gynecol Obstet. 1981 Sep;153(3):417-31.
Antibody may sensitize tumor cells for destruction by nonimmune host effector elements that include complement, macrophages, lymphocytes, neutrophils, eosinophils or platelets. Small numbers of tumor cells may be very efficiently suppressed in vivo. Antibody immunotherapy can also be used successfully in combination with other modalities, such as chemotherapy, in the treatment of larger tumor burdens. Perhaps the greatest potential application of antibody in cancer therapy is its use as a tumor-specific delivery vehicle for cytotoxic substances. The opportunity to produce large quantities of monoclonal antibody, afforded by current hybridoma technology, will revolutionize the application of antibody to cancer medicine.
抗体可使肿瘤细胞对包括补体、巨噬细胞、淋巴细胞、中性粒细胞、嗜酸性粒细胞或血小板在内的非免疫宿主效应元件的破坏敏感。少量肿瘤细胞在体内可能被非常有效地抑制。抗体免疫疗法也可成功地与其他治疗方式（如化疗）联合用于治疗更大的肿瘤负荷。抗体在癌症治疗中最具潜力的应用可能是将其用作细胞毒性物质的肿瘤特异性递送载体。当前杂交瘤技术提供了大量生产单克隆抗体的机会，这将彻底改变抗体在癌症医学中的应用。
