Epstein E
Arch Dermatol. 1977 Jul;113(7):906-8.
Topical (5-fluorouracil [5-FU]) as a 5% solution was used to treat isolated actinic keratoses of the lips as well as diffuse actinic damage of the lower lip. Although producing considerable temporary discomform final results proved excellent, with recurrences in only two of 12 patients treated. Preliminary biopsy of suspicious infiltrated areas is mandatory, as is careful follow-up to ensure complete healing. Topical fluorouracil is an alternative to surgical excision of the vermillion border of the lip in those patients with severe diffuse actinic damage of the lips.
外用5%溶液的5-氟尿嘧啶（5-FU）用于治疗唇部孤立性光化性角化病以及下唇的弥漫性光化性损伤。尽管会产生相当程度的暂时不适，但最终结果极佳，接受治疗的12例患者中仅2例复发。对可疑浸润区域进行初步活检是必要的，仔细随访以确保完全愈合也同样必要。对于唇部有严重弥漫性光化性损伤的患者，外用氟尿嘧啶是唇部红唇缘手术切除的一种替代方法。
