Genetic analysis of HLA in psoriasis.

The results of HLA typing in the sample of 39 families were used for the evaluation of inheritance mode in psoriasis. To discriminate between autosomal dominant and autosomal recessive models of inheritance of "disease" genes Thompson's and Bodmer's method was applied. The distributions of genotypes with HLA-B13 or HLA-B17 did not allow to differentiate between dominant and recessive inheritance pattern. Also the comparison of observed and expected numbers of sib paris sharing two, one or no HLA haplotypes was considered. The attempts to confirm dominant and recessive model in our sample failed. However, the high values of chi-square were due only to the difference among sib pairs with no common HLA haplotypes.