Miggiano G A, Mordente A, Martorana G E, Meucci E, Castelli A
Enzyme. 1983;30(2):145-8. doi: 10.1159/000469564.
Ascorbic acid is found strikingly to decrease the activity of bovine kidney alkaline phosphatase in vitro. The inhibition of alkaline phosphatase is a function of ascorbic acid concentration and is time and temperature dependent. The presence of the substrate protects the enzyme against the inhibitory action of the vitamin.
