Zaks A S, Bykova A A, Evteeva T A
Farmakol Toksikol. 1978 Sep-Oct;41(5):594-7.
In blood of patients with diabetes mellitus receiving bucarban or adebit antibodies to these drugs were discovered. Patients medicated with bucarban demonstrated an elevated content of antibodies to insulin. The appearance of specific antibodies occurred in rabbits and rats following introduction of bucarban, glucophage or adebit per se or when mixed with adjuvants. An increased production of antibodies to endogenous insulin was observed in all animals reveiving bucarban. Introduction to rats of inactivated (at 56 degrees C for 30 minutes) serum of patients with diabetes mellitus that contained antibodies to bucarban or adebit as well as immune rabbit sera greatly mitigated the hypoglycemic effect of the latter. Introduction to rats of the blood serum taken in patients reveiving bucarban allso attenuated the effect of exogenous insulin. These findings suggest that, possessing neutralizing properties, these antibodies to bucarban, adebit and glucophage cause habituation to these substances. Accumulation in the blood of autoantibodies to insulin following introduction of bacarban reduces the sensitivity to the exogenous hormone and manifests the existence of an immune mechanism securing the preservation of chemical homeostasis in the organism.
在接受布卡班或阿德比特治疗的糖尿病患者血液中发现了针对这些药物的抗体。使用布卡班治疗的患者体内胰岛素抗体含量升高。在兔子和大鼠中，单独引入布卡班、二甲双胍或阿德比特，或与佐剂混合后，会出现特异性抗体。在所有接受布卡班治疗的动物中，均观察到内源性胰岛素抗体产生增加。给大鼠注射含有针对布卡班或阿德比特抗体的糖尿病患者经56℃加热30分钟灭活的血清以及免疫兔血清，可大大减轻后者的降血糖作用。给大鼠注射接受布卡班治疗患者的血清也会减弱外源性胰岛素的作用。这些发现表明，这些针对布卡班、阿德比特和二甲双胍的抗体具有中和特性，会导致对这些物质产生适应性。引入布卡班后血液中胰岛素自身抗体的积累会降低对外源激素的敏感性，并表明存在一种免疫机制来确保机体化学稳态的维持。
