Jensen D M, McFarlane I G, Portmann B S, Eddleston A L, Williams R
N Engl J Med. 1978 Jul 6;299(1):1-7. doi: 10.1056/NEJM197807062990101.
A specific and sensitive radioimmunoassay was used to measure the levels of antibody to a liver-specific membrane lipoprotein in patients with acute and chronic liver disease. Antibody was detected in 29 of 30 patients with chronic active hepatitis (all of 15 HBsAg-negative and 14 of 15 HBsAg-positive cases), and in 10 of 17 patients with chronic persistent hepatitis but at significantly lower titer. The titer of antibody to the lipoprotein showed a significant correlation with activity of disease as judged histologically and biochemically. Transiently elevated levels were found in 20 of 21 patients with acute viral hepatitis, but there was no correlation with the degree of liver damage. Antibody to liver-specific membrane protein may be part of the final common pathway of liver-cell damage in both HBsAg-positive and HBsAg-negative chronic activite hepatitis, whereas other immune mechanisms determine the liver-cell injury in acute viral hepatitis.
采用一种特异性和敏感性均较高的放射免疫分析法，测定急慢性肝病患者体内针对一种肝脏特异性膜脂蛋白的抗体水平。在30例慢性活动性肝炎患者中，有29例检测到抗体（15例HBsAg阴性患者全部阳性，15例HBsAg阳性患者中有14例阳性）；17例慢性持续性肝炎患者中有10例检测到抗体，但滴度显著较低。脂蛋白抗体滴度与经组织学和生化检查判断的疾病活动度显著相关。21例急性病毒性肝炎患者中有20例出现短暂性抗体水平升高，但与肝损伤程度无关。在HBsAg阳性和HBsAg阴性的慢性活动性肝炎中，肝脏特异性膜蛋白抗体可能是肝细胞损伤最终共同途径的一部分，而在急性病毒性肝炎中，其他免疫机制决定肝细胞损伤。
