Rodríguez N, Hernández A G, Merino F
Int Arch Allergy Appl Immunol. 1983;72(3):206-10. doi: 10.1159/000234869.
The effect of a purified glycoprotein excreted to the culture medium by Leishmania brasiliensis on the endocytic and degradative capacity of macrophages was studied. It was demonstrated that 125I-albumin incorporation as well as its intracellular fate by mouse peritoneal or tumor J774-G8 macrophages was greatly reduced when they were treated with excreted factor (EF). EF appears to alter also membrane properties in addition to its intracellular effect. The results are discussed in relation to the Leishmania survival mechanism inside the host macrophages and its pathogenicity.
研究了巴西利什曼原虫分泌到培养基中的一种纯化糖蛋白对巨噬细胞内吞和降解能力的影响。结果表明，用分泌因子（EF）处理小鼠腹腔巨噬细胞或肿瘤J774-G8巨噬细胞后，其对125I-白蛋白的摄取及其在细胞内的命运均大大降低。EF除了具有细胞内效应外，似乎还能改变细胞膜特性。结合利什曼原虫在宿主巨噬细胞内的生存机制及其致病性对这些结果进行了讨论。
