Nakajo M, Nakabeppu Y, Iwashita S, Shinohara S
Department of Radiology, Faculty of Medicine, Kagoshima University, Japan.
Ann Nucl Med. 1990 Jul;4(2):49-54. doi: 10.1007/BF03164595.
Variations in heart intensity in the 30 min and 4 hr chest images of the radiolabelled lipophilic amine, N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) were observed in 130 patients with lung diseases, aged 23 to 85 yrs. The heart intensity had a significant positive linear correlation with age (r = 0.43 at 30 min, 0.66 at 4 hr). The ratio of 4 hr heart intensity to 30 min heart intensity also had a positive linear correlation (r = 0.59), suggesting slower clearance of the radioactivity from the heart in older than in younger patients during this interval. Other parameters including sex, EKG findings, liver function, blood pressure, the presence of diabetes mellitus and smoking history had no relationship to heart intensity. A significant difference between heart intensities in bronchogenic carcinoma and pneumonia patient groups might be probably due to the age difference between the two groups. Therefore heart intensity in the 4 hr 123I-IMP image may reflect certain metabolic and/or myocardial change(s) with aging.
在130例年龄在23至85岁的肺部疾病患者中，观察到放射性标记的亲脂性胺N-异丙基-p-[123I]碘安非他明（123I-IMP）在30分钟和4小时胸部图像中心脏放射性强度的变化。心脏放射性强度与年龄呈显著正线性相关（30分钟时r = 0.43，4小时时r = 0.66）。4小时心脏放射性强度与30分钟心脏放射性强度的比值也呈正线性相关（r = 0.59），表明在此期间老年患者心脏放射性清除比年轻患者慢。包括性别、心电图结果、肝功能、血压、糖尿病的存在和吸烟史在内的其他参数与心脏放射性强度无关。支气管肺癌和肺炎患者组心脏放射性强度的显著差异可能是由于两组之间的年龄差异。因此，4小时123I-IMP图像中的心脏放射性强度可能反映了随着年龄增长的某些代谢和/或心肌变化。
