Ueda T, Kinoshita K, Watanabe K, Hoshi H, Jinnouchi S
Department of Neurosurgery, Miyazaki Medical College, Japan.
Neuroradiology. 1988;30(2):123-31. doi: 10.1007/BF00395613.
Early and delayed single photon emission computed tomography (SPECT) using N-isopropyl-p-(123I)iodoamphetamine (IMP) was performed on 28 subjects (2 normal, 12 with cerebrovascular diseases and 14 with brain tumors) to evaluate the reversibility of the cerebral abnormality and cerebral viability. The results were compared with X-ray CT, 99mTc brain scintigraphy and rCBF by 133Xe inhalation method. Three types of IMP kinetics were observed. Initial hypoactivity that changed over 4 to 6 hours approaching a normal pattern suggests a hypofunctional parenchyma without significant tissue damage: long-lasting abnormalities on IMP SPECT indicates cellular damage.
对28名受试者（2名正常、12名患有脑血管疾病和14名患有脑肿瘤）进行了早期和延迟单光子发射计算机断层扫描（SPECT），使用N-异丙基-p-（123I）碘安非他明（IMP）来评估脑异常的可逆性和脑存活能力。将结果与X射线CT、99mTc脑闪烁显像以及通过133Xe吸入法测定的局部脑血流量（rCBF）进行比较。观察到三种类型的IMP动力学。最初的活性降低在4至6小时内发生变化并接近正常模式，提示实质功能减退但无明显组织损伤：IMP SPECT上持续存在的异常表明细胞损伤。
