Sone H, Takayanagi I
J Pharmacobiodyn. 1983 Apr;6(4):272-4. doi: 10.1248/bpb1978.6.272.
Newly synthesized compound, 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy)phenyl]acrylonitrile (SX-284) inhibited electrically evoked acetylcholine release from the stores in the myenteric plexus-longitudinal strips of guinea pig ileum which was labelled with [3H]-choline but not the evoked release of tracer from rat vas deferens after labelling with [3H]-norepinephrine. These results support our previous findings that SX-284 specifically inhibit acetylcholine release from the vagus nerve in the gastrointestinal canal.
新合成的化合物2-(1,2-苯并异恶唑-3-基)-3-[2-(2-哌啶基乙氧基)苯基]丙烯腈（SX-284）抑制了用电刺激从豚鼠回肠肌间神经丛-纵行肌条中储存部位释放的乙酰胆碱，该肌条用[3H]-胆碱标记，但不抑制用[3H]-去甲肾上腺素标记后大鼠输精管中示踪剂的诱发释放。这些结果支持了我们之前的发现，即SX-284特异性抑制胃肠道中迷走神经释放乙酰胆碱。
