[Functional state of cytoplasmic reticulum of hepatocytes in rats with acute kidney insufficiency].

In acute rat kidney insufficiency, caused by bilateral nephrectomy or ureter ligation, functional activity of hepatocyte cytoplasmic structure was decreased. Estimation of the cytoplasmic structures functional state included studies of hexenal anesthesia duration, determination of cytochromes P-450 and b5 content in liver microsomal fraction as well as of activities of amidopyrine-N-demethylase and aniline hydroxylase. The alterations of these parameters occurred apparently due to the effect of high concentrations of urea on liver tissue.