Khakimov Z Z, Krakovskiĭ M E, Nadzhimutdinov K N, Karabanovich A K
Vopr Med Khim. 1983 Jul-Aug;29(4):30-3.
In acute rat kidney insufficiency, caused by bilateral nephrectomy or ureter ligation, functional activity of hepatocyte cytoplasmic structure was decreased. Estimation of the cytoplasmic structures functional state included studies of hexenal anesthesia duration, determination of cytochromes P-450 and b5 content in liver microsomal fraction as well as of activities of amidopyrine-N-demethylase and aniline hydroxylase. The alterations of these parameters occurred apparently due to the effect of high concentrations of urea on liver tissue.
在由双侧肾切除或输尿管结扎引起的急性大鼠肾功能不全中，肝细胞胞质结构的功能活性降低。对胞质结构功能状态的评估包括对己烯醛麻醉持续时间的研究、肝微粒体部分中细胞色素P - 450和b5含量的测定以及氨基比林 - N - 脱甲基酶和苯胺羟化酶活性的测定。这些参数的改变显然是由于高浓度尿素对肝脏组织的影响所致。
