Volovik V M, Sheĭnina N S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(8):1205-11.
Altogether 255 patients with slow-progressive schizophrenia were examined, the mean time of follow up studies being 5.7 years. Premorbid anamnesis of the 93 patients showed different dysfunctional states (psychopathologic, neurologic or somatovegetative of transient character). As regards the structure and development these disorders were not related to the disease that followed. The character of the dysfunctional states, progress of the disease, syndromic manifestations during active period and marked negative changes during the remission seemed to be linked. In patients with early dysfunctional states, the disease ran a more favourable course. Greater severity, systemic character as well as symptomatic features marked early dysfunctional states in patients with schizophrenia as compared to those seen in neurotic patients. Early dysfunctional states are assumed to be a manifestation of instability of the functional systems as a result of their concealed reconstruction during latent disease stage.
共检查了255例缓慢进展型精神分裂症患者，随访研究的平均时间为5.7年。93例患者的病前记忆显示出不同的功能障碍状态（精神病理、神经或短暂性躯体自主功能障碍）。就其结构和发展而言，这些障碍与随后发生的疾病无关。功能障碍状态的特征、疾病进展、活动期的综合征表现以及缓解期明显的阴性变化似乎相互关联。在早期出现功能障碍状态的患者中，疾病的病程更为有利。与神经症患者相比，精神分裂症患者早期功能障碍状态的严重程度更高、具有系统性特征以及症状更为明显。早期功能障碍状态被认为是由于在疾病潜伏期功能系统的隐匿性重构导致功能系统不稳定的一种表现。
